Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice
نویسندگان
چکیده
Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110; and Center for Human Genetic Research, Department of Neurology, Massachusetts General Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115
منابع مشابه
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice.
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. LRRK2 is a large protein containing a small GTPase domain and a kinase domain, but its physiological role is unknown. To identify the normal function of LRRK2 in vivo, we generated two independent lines of germ-line deletion mice. The dopaminergic system of LRRK2(-/-) mice appears normal,...
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